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Much of Neanderthal genetic diversity came from modern humans

A large, brown-colored skull seen in profile against a black background.

Enlarge (credit: Halamka)

The basic outline of the interactions between modern humans and Neanderthals is now well established. The two came in contact as modern humans began their major expansion out of Africa, which occurred roughly 60,000 years ago. Humans picked up some Neanderthal DNA through interbreeding, while the Neanderthal population, always fairly small, was swept away by the waves of new arrivals.

But there are some aspects of this big-picture view that don't entirely line up with the data. While it nicely explains the fact that Neanderthal sequences are far more common in non-African populations, it doesn't account for the fact that every African population we've looked at has some DNA that matches up with Neanderthal DNA.

A study published on Thursday argues that much of this match came about because an early modern human population also left Africa and interbred with Neanderthals. But in this case, the result was to introduce modern human DNA to the Neanderthal population. The study shows that this DNA accounts for a lot of Neanderthals' genetic diversity, suggesting that their population was even smaller than earlier estimates had suggested.

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High-altitude cave used by Tibetan Buddhists yields a Denisovan fossil

Image of a sheer cliff face with a narrow path leading to a cave opening.

Enlarge / The Baishiya Karst Cave, where the recently analyzed samples were obtained. (credit: Dongju Zhang’s group (Lanzhou University))

For well over a century, we had the opportunity to study Neanderthalsβ€”their bones, the items they left behind, their distribution across Eurasia. So, when we finally obtained the sequence of their genome and discovered that we share a genetic legacy with them, it was easy to place the discoveries into context. By contrast, we had no idea Denisovans existed until sequencing DNA from a small finger bone revealed that yet another relative of modern humans had roamed Asia in the recent past.

Since then, we've learned little more. The frequency of their DNA in modern human populations suggests that they were likely concentrated in East Asia. But we've only discovered fragments of bone and a few teeth since then, so we can't even make very informed guesses as to what they might have looked like. On Wednesday, an international group of researchers described finds from a cave on the Tibetan Plateau that had been occupied by Denisovans, which tell us a bit more about these relatives: what they ate. And that appears to be anything they could get their hands on.

The Baishiya Karst Cave

The finds come from a site called the Baishiya Karst Cave, which is perched on a cliff on the northeast of the Tibetan Plateau. It's located at a high altitude (over 3,000 meters or nearly 11,000 feet) but borders a high open plain, as you can see in the picture below.

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